| First Author | Ma J | Year | 1996 |
| Journal | Am J Physiol | Volume | 271 |
| Issue | 4 Pt 2 | Pages | H1717-9 |
| PubMed ID | 8897969 | Mgi Jnum | J:36238 |
| Mgi Id | MGI:83682 | Doi | 10.1152/ajpheart.1996.271.4.H1717 |
| Citation | Ma J, et al. (1996) L-NNA-sensitive regional cerebral blood flow augmentation during hypercapnia in type III NOS mutant mice. Am J Physiol 271(4 Pt 2):H1717-9 |
| abstractText | The effect of NG-nitro-L-arginine (L-NNA) on regional cerebral blood flow (rCBF) response to hypercapnia (5% CO2 inhalation) was studied in urethan-anesthetized wild-type (SV-129) and type III nitric oxide (NO) synthase (NOS)-deficient mice, using laser-Doppler flowmetry and the closed cranial window technique. Resting rCBF during normocapnia decreased by approximately 25% after L-NNA superfusion in wild-type mice only (n = 18), suggesting a role for type III NOS in baseline blood flow. Hypercapnia augmented rCBF approximately 50% in both wild-type and type III NOS mutant mice. L-NNA superfusion (1 mM) inhibited this increase by approximately 60% in both strains. Hence, synthesis of NO by the constitutively expressed type I NOS contributes to blood flow augmentation during hypercapnia. |
