| First Author | Miyatake R | Year | 1996 |
| Journal | FEBS Lett | Volume | 395 |
| Issue | 2-3 | Pages | 123-6 |
| PubMed ID | 8898078 | Mgi Jnum | J:36013 |
| Mgi Id | MGI:83456 | Doi | 10.1016/0014-5793(96)01022-8 |
| Citation | Miyatake R, et al. (1996) Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA. FEBS Lett 395(2-3):123-6 |
| abstractText | We detected alternative splicing of the mouse brain type ryanodine receptor (RyR3) mRNA. The splicing variant was located in the transmembrane segment. The non-splicing type (RyR3-II) included a stretch of 341 bp, and that of the 13th codon was stop codon TAA. Reverse transcription-polymerase chain reaction (RT-PCR) analysis shows that RyR3-II mRNA was expressed in various peripheral tissues and brain at all developmental stages. However, interestingly, the splicing type (RyR3-I) mRNA was detected only in the cerebrum. These findings suggest that the splicing variants RyR3-I and RyR3-II may generate functional differences of RyR3 in a tissue-specific manner. |
