| First Author | Parker NJ | Year | 1996 |
| Journal | Genomics | Volume | 37 |
| Issue | 2 | Pages | 253-6 |
| PubMed ID | 8921403 | Mgi Jnum | J:36007 |
| Mgi Id | MGI:83450 | Doi | 10.1006/geno.1996.0553 |
| Citation | Parker NJ, et al. (1996) Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5. Genomics 37(2):253-6 |
| abstractText | A novel gene (GOK) has been cloned from human chromosome region 11p15.5 that is believed to contain a gene or genes associated with a number of pediatric malignancies, including Wilms tumor. A 4-kb cDNA has been cloned and it encodes a predicted protein of approximately 84 kDa that could be translated in vitro. Computer analysis predicted that the protein had a signal peptide and may contain a transmembrane helix. Restriction mapping by pulsed-field electrophoresis indicates that GOK is located 1.7 kb telomeric of RRM1, and both genes are transcribed in the same direction. GOK displays high evolutionary conservation: cloning and partial sequencing of a mouse genomic clone revealed 90% identity with the human gene at both the nucleotide and the predicted amino acid levels. |
