| First Author | Korte SM | Year | 1996 |
| Journal | Brain Res | Volume | 736 |
| Issue | 1-2 | Pages | 338-43 |
| PubMed ID | 8930340 | Mgi Jnum | J:36222 |
| Mgi Id | MGI:83661 | Doi | 10.1016/0006-8993(96)00723-8 |
| Citation | Korte SM, et al. (1996) Enhanced 5-HT1A receptor expression in forebrain regions of aggressive house mice. Brain Res 736(1-2):338-43 |
| abstractText | The brain 5-HT1A receptor system in male wild house mice selected for high and low offensive aggression was investigated by autoradiographic analysis of in situ hybridization and radioligand binding. In high-aggressive mice, characterized by a short attack latency, the rise in plasma corticosterone concentration during the early dark phase was reduced. At that time the level of 5-HT1A mRNA in the dorsal hippocampus (dentate gyrus and CA1) was twice the amount measured in low-aggressive mice that had long attack latency and high plasma corticosterone level. Increased postsynaptic 5-HT1A receptor radioligand binding was found in dentate gyrus, CA1, lateral septum, and frontal cortex. No difference in ligand binding was found for the 5-HT1A autoreceptor on cell bodies in the dorsal raphe nucleus. In conclusion, genetic selection for high offensive aggression co-selects for reduced (circadian peak) level in plasma corticosterone and increased postsynaptic 5-HT1A receptor number in limbic and cortical regions. |
