| First Author | Miller B | Year | 1996 |
| Journal | J Immunol | Volume | 157 |
| Issue | 12 | Pages | 5324-8 |
| PubMed ID | 8955179 | Mgi Jnum | J:37110 |
| Mgi Id | MGI:84538 | Doi | 10.4049/jimmunol.157.12.5324 |
| Citation | Miller B (1996) delta opioid receptor expression is induced by concanavalin A in CD4+ T cells. J Immunol 157(12):5324-8 |
| abstractText | Expression of delta opioid receptor mRNA in CD4+ T cells purified from Con A-stimulated murine splenocytes was demonstrated by reverse transcription-PCR and sequencing of the PCR products. mu and kappa opioid receptor mRNAs were not detected. Similar results were obtained in a single isolation of CD8+ T cells from Con A-stimulated splenocytes. mRNA for the delta opioid receptor was not detected in CD4+ T cells purified from either freshly isolated splenocytes or splenocytes cultured without Con A, and incubation of purified CD4+ T cells with Con A did not induce delta opioid receptor mRNA. It appears that quiescent CD4+ T cells do not express classic opioid receptors, but the delta-type receptor can be induced upon activation. |
