| First Author | McLoughlin DM | Year | 1996 |
| Journal | FEBS Lett | Volume | 397 |
| Issue | 2-3 | Pages | 197-200 |
| PubMed ID | 8955346 | Mgi Jnum | J:36747 |
| Mgi Id | MGI:84173 | Doi | 10.1016/s0014-5793(96)01128-3 |
| Citation | McLoughlin DM, et al. (1996) The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. FEBS Lett 397(2-3):197-200 |
| abstractText | We have used the yeast two-hybrid system to screen for proteins that interact with the carboxy-terminal domain of APP. Six different clones were isolated and sequence analyses revealed that they encoded domains of a previously described neuronal protein Fe65, a homologue of Fe65 and a homologue of protein X11. All of these proteins contain one or more phosphotyrosine binding (PTB) domains. PTB domain proteins bind to the sequence Asn-Pro-X-Tyr when the Tyr is phosphorylated and are believed to function in signal transduction. APP contains such a motif. These results are consistent with a role for APP in signal transduction mechanisms. |
