| First Author | Molven A | Year | 1996 |
| Journal | Genomics | Volume | 38 |
| Issue | 1 | Pages | 72-5 |
| PubMed ID | 8954781 | Mgi Jnum | J:36980 |
| Mgi Id | MGI:84386 | Doi | 10.1006/geno.1996.0593 |
| Citation | Molven A, et al. (1996) Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23. Genomics 38(1):72-5 |
| abstractText | The four members of the Fos gene family give rise to proteins that are part of the AP-1 transcription factor complex. When studying cAMP-induced apoptosis in a leukemia cell line from rat, we found that the Fra-2 gene (coding for the Fos-related antigen-2) became strongly upregulated as the leukemia cells started to die. It was therefore of interest to determine the cytogenetic localization of the human Fra-2 gene (FRA2), including a comparison to chromosomal aberrations observed in leukemia patients. Based on sequence information from the rat and chicken Fra-2 homologs, we were able to PCR-amplify a 4.5-kb genomic fragment covering exon 4 of FRA2. This fragment was employed as probe for both radioactive and fluorescence in situ hybridization to human metaphase chromosomes, allowing us to assign FRA2 to 2p22-p23. The localization of the gene to chromosome 2 was independently verified by PCR amplification of a FRA2-specific fragment from a panel of rodent-human somatic cell hybrids. |
