| First Author | Schön MP | Year | 1997 |
| Journal | Nat Med | Volume | 3 |
| Issue | 2 | Pages | 183-8 |
| PubMed ID | 9018237 | Mgi Jnum | J:38128 |
| Mgi Id | MGI:85515 | Doi | 10.1038/nm0297-183 |
| Citation | Schon MP, et al. (1997) Murine psoriasis-like disorder induced by naive CD4+ T cells. Nat Med 3(2):183-8 |
| abstractText | Psoriasis is a complex disorder involving alterations of many cell types. Although evidence suggests a T-cell pathogenesis for psoriasis, a primary role of T cells has not been directly demonstrated. Here, we show that reconstitution of scid/scid mice with minor histocompatibility mismatched naive CD4+ T lymphocytes resulted in skin alterations that strikingly resembled human psoriasis clinically, histopathologically and in cytokine expression. This skin disorder was diminished when memory T cells were coinjected. Thus, a subset of dysregulated CD4+ T cells can cause tissue alterations seen in psoriasis without the presence of CD8+ cells or a primary epithelial abnormality. |
