| First Author | Galvin-Parton PA | Year | 1997 |
| Journal | J Biol Chem | Volume | 272 |
| Issue | 7 | Pages | 4335-41 |
| PubMed ID | 9020153 | Mgi Jnum | J:38690 |
| Mgi Id | MGI:86072 | Doi | 10.1074/jbc.272.7.4335 |
| Citation | Galvin-Parton PA, et al. (1997) Induction of Galphaq-specific antisense RNA in vivo causes increased body mass and hyperadiposity. J Biol Chem 272(7):4335-41 |
| abstractText | Transgenic BDF-1 mice harboring an inducible, tissue-specific transgene for RNA antisense to Galphaq provide a model in which to study a loss-of-function mutant of Galphaq in vivo. Galphaq deficiency induced in liver and white adipose tissue at birth produced increased body mass and hyperadiposity within 5 weeks of birth that persisted throughout adult life. Galphaq-deficient adipocytes display reduced lipolytic responses, shown to reflect a newly discovered, alpha1-adrenergic regulation of lipolysis. This alpha1-adrenergic response via phosphoinositide hydrolysis and activation of protein kinase C is lacking in the Galphaq loss-of-function mutants in vivo and provides a basis for the increased fat accumulation. |
