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Publication : Expression of glutamate receptor subunit genes during development of the mouse retina.

First Author  Zhang C Year  1996
Journal  Neuroreport Volume  8
Issue  1 Pages  335-40
PubMed ID  9051806 Mgi Jnum  J:40542
Mgi Id  MGI:700183 Doi  10.1097/00001756-199612200-00066
Citation  Zhang C, et al. (1996) Expression of glutamate receptor subunit genes during development of the mouse retina. Neuroreport 8(1):335-40
abstractText  The distribution of expression during retinal differentiation of nine AMPA and kainate glutamate receptor subunit genes was studied by in situ hybridization. Transcripts encoding all subunits were detected in the inner nuclear and ganglion cell layers of the developing mouse retina, but their time courses of expression differed. The earliest expression was detected at embryonic day 14 (E14) for GluR1, GluR4 and KA-2; all the other subunits were first detected at E16. Most subunits were expressed at higher levels during development than in the adult. This suggests they play a role in the processes of neuronal differentiation and synaptogenesis that occur during the early postnatal days in the rodent retina.
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