| First Author | Weil D | Year | 1997 |
| Journal | Gene | Volume | 187 |
| Issue | 1 | Pages | 115-22 |
| PubMed ID | 9073074 | Mgi Jnum | J:39137 |
| Mgi Id | MGI:86518 | Doi | 10.1016/s0378-1119(96)00733-0 |
| Citation | Weil D, et al. (1997) Antisense transcription of a murine FGFR-3 psuedogene during fetal developement. Gene 187(1):115-22 |
| abstractText | In a search for new protein tyrosine kinases (PTKs) in early hemopoietic cells, we have identified a sequence closely related to the Fibroblast Growth Factor Receptor (FGFR) family. A cDNA isolated from a mouse embryo library was 89% identical to FGFR-3 in both its coding and 3' untranslated regions. However, the region homologous to exons 5 to 9 of FGFR-3 was missing. In addition, the ORF was interrupted by several stop codons and frame shifts, indicating that this sequence is not functional. These transcripts were therefore copied from a novel FGFR-3 pseudogene, that we called psi FGFR-3. Partial analysis of this gene showed the absence of introns, which is a characteristic feature of a processed pseudogene. Psi FGFR- 3 gene was localized on Chromosome 1H4-6. Its transcription was shown to be antisense and its expression was restricted to fetal tissues. These results indicate that psi FGFR-3 has been inserted in Chromosome 1 in antisense orientation dose to a heterologous promoter. |
