First Author | Procaccio V | Year | 1997 |
Journal | Biochim Biophys Acta | Volume | 1351 |
Issue | 1-2 | Pages | 37-41 |
PubMed ID | 9116042 | Mgi Jnum | J:39715 |
Mgi Id | MGI:87068 | Doi | 10.1016/s0167-4781(97)00020-1 |
Citation | Procaccio V, et al. (1997) cDNA sequence and chromosomal localization of the NDUFS8 human gene coding for the 23 kDa subunit of the mitochondrial complex I. Biochim Biophys Acta 1351(1-2):37-41 |
abstractText | We have sequenced the cDNA for the 23 kDa subunit of the human mitochondrial respiratory complex I. The deduced protein consists of 210 amino acids (Mr = 23705 Da) with a 34 amino acid N terminus presumably acting as a presequence for mitochondrial import. The predicted mature protein (Mr = 20290 Da) is 92% identical to the bovine mitochondrial subunit and 72% to the Rhodobacter capsulatus NUOI counterpart. Two clusters of four cysteine residues are conserved among these proteins. The gene (NDUFS8) coding for the human subunit has been mapped to chromosome 11q13. |