| First Author | Leclerc C | Year | 1997 |
| Journal | J Immunol | Volume | 158 |
| Issue | 7 | Pages | 3252-8 |
| PubMed ID | 9120281 | Mgi Jnum | J:39936 |
| Mgi Id | MGI:87278 | Doi | 10.4049/jimmunol.158.7.3252 |
| Citation | Leclerc C, et al. (1997) Control by Ig genes of the responsiveness to a neutralization viral B cell epitope. J Immunol 158(7):3252-8 |
| abstractText | In the present study, we analyzed the capacity of seven strains of mice to produce Abs against the neutralization poliovirus C3 B cell epitope, chemically or genetically linked to two different carrier proteins (MalE and keyhole limpet hemocyanin) or to recombinant hepatitis B surface Ag particles. Following immunization with these different immunogens, all strains of mice developed high Ab titers against the carrier proteins. However, only four strains of mice developed a significant Ab response against the poliovirus C3 B cell epitope. Indeed, in contrast to BALB/c, DBA/1, DBA/2, and 129 sv mice, C57BL/6, C3H, and CBA/J mice failed to produce anti-C3 Abs after immunization with the various C3 immunogens. Using various H-2 congenic strains on BALB/c or C57BL/10 background, this study clearly showed that the response to the C3 B cell epitope is not controlled by MHC genes. In contrast, analysis of anti-C3 Ab responses in IgH congenic mouse lines on BALB/c or C57BL/6 background demonstrated that the capacity to respond to this B cell epitope is controlled by genes closely linked to V(H) genes. This study therefore represents the first demonstration that the V(H) polymorphism can limit the Ab response to a viral neutralization epitope, and therefore has important implications for vaccine development. |
