| First Author | Lee JT | Year | 1997 |
| Journal | Curr Opin Genet Dev | Volume | 7 |
| Issue | 2 | Pages | 274-80 |
| PubMed ID | 9115428 | Mgi Jnum | J:39951 |
| Mgi Id | MGI:87293 | Doi | 10.1016/s0959-437x(97)80138-4 |
| Citation | Lee JT, et al. (1997) The (epi)genetic control of mammalian X-chromosome inactivation. Curr Opin Genet Dev 7(2):274-80 |
| abstractText | In mammals, the X chromosome is uniquely capable of complete inactivation. Research in the past two years has validated the long-held hypothesis that the 'X-inactivation center' (Xic) controls events of X inactivation and that its resident gene Xist is not only required but is at least partially responsible for the cis-restriction of X inactivation. Progress has also been made in identifying genes within the Xic. Although Xist remains the only known required element, evidence now suggests that a separate element for X counting must exist and that the Xic may be entirely contained within a 450 kb sequence. This small region may be sufficient for both initiation and establishment of X inactivation. |
