| First Author | Jay P | Year | 1997 |
| Journal | Oncogene | Volume | 14 |
| Issue | 14 | Pages | 1753-7 |
| PubMed ID | 9135077 | Mgi Jnum | J:39750 |
| Mgi Id | MGI:87099 | Doi | 10.1038/sj.onc.1200986 |
| Citation | Jay P, et al. (1997) The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p. Oncogene 14(14):1753-7 |
| abstractText | Complementary DNA encoding the human CYR61 protein was isolated from human embryonic tissues and mapped to chromosome 1p22-p31. We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue. Sequence analysis reveals the presence of several distinct protein domains which confer a mosaic structure to this protein and makes human CYR61 a member of a recently described growth regulator family that includes several proto-oncogene products. From our results we hypothesize that this new immediate early gene may play a role in cell commitment during embryogenesis and more generally in the control of cell proliferation. |
