| First Author | Heath SK | Year | 1997 |
| Journal | Hum Mol Genet | Volume | 6 |
| Issue | 5 | Pages | 651-7 |
| PubMed ID | 9158137 | Mgi Jnum | J:40220 |
| Mgi Id | MGI:87562 | Doi | 10.1093/hmg/6.5.651 |
| Citation | Heath SK, et al. (1997) Characterisation of expression of mDMAHP, a homeodomain-encoding gene at the murine DM locus. Hum Mol Genet 6(5):651-7 |
| abstractText | We examined the expression of the murine homologue of myotonic dystrophy associated homeodomain protein (mDMAHP) using two different strategies. The first approach, RT-PCR, detected spliced transcripts in a wide range of embryonic and adult tissues, in a pattern overlapping substantially with the expression of mDMPK. A second approach, the generation of transgenic mice expressing the lacZ reporter gene from a 4.3 kb promoter fragment, also demonstrated expression in a range of tissues with potential links to the phenotype in myotonic dystrophy. We conclude that murine DMAHP has a similar pattern of expression to human DMAHP and will serve as a useful model for functional studies of this gene, although species differences, such as the reduced CpG island (1.8 kb compared with 3.5 kb) must be carefully considered. |
