| First Author | Mikulowska A | Year | 1997 |
| Journal | J Immunol | Volume | 158 |
| Issue | 11 | Pages | 5514-7 |
| PubMed ID | 9164975 | Mgi Jnum | J:40636 |
| Mgi Id | MGI:707991 | Doi | 10.4049/jimmunol.158.11.5514 |
| Citation | Mikulowska A, et al. (1997) Macrophage migration inhibitory factor is involved in the pathogenesis of collagen type II-induced arthritis in mice. J Immunol 158(11):5514-7 |
| abstractText | To determine the importance of macrophage migration inhibitory factor (MIF) in the development of arthritis we used an experimental model for rheumatoid arthritis, collagen type II (CII)-induced arthritis in mice. Treatment with neutralizing anti-MIF Abs before immunization of (B10.Q x DBA/1)F1 with CII led to delayed onset and lowered frequency of arthritis. This was associated with lower levels of IgG2a to CII in MIF-depleted mice. The proliferative response to CII was stronger in the anti-MIF-treated mice, whereas no significant effects were seen on Ag-induced IFN-gamma production in response to CII or on the total serum Ab levels in response to CII. These results provide the first experimental evidence of a role for MIF in the pathogenesis of autoimmune disease. |
