| First Author | Borst P | Year | 1997 |
| Journal | Trends Genet | Volume | 13 |
| Issue | 6 | Pages | 217-22 |
| PubMed ID | 9196326 | Mgi Jnum | J:41067 |
| Mgi Id | MGI:892805 | Doi | 10.1016/S0168-9525(97)01112-8 |
| Citation | Borst P, et al. (1997) Genetic dissection of the function of mammalian P-glycoproteins. Trends Genet 13(6):217-22 |
| abstractText | Mammalian P-glycoproteins are plasma membrane proteins belonging to the superfamily of ATP-binding cassette transporters. They were discovered as drug pumps in multidrug-resistant cancer cells, but are also present in many normal tissues. Genetic approaches have helped to dissect the physiological functions and mode of action of P-glycoproteins. Disruption of both genes for the drug-transporting P-glycoproteins in mice has no effect on the normal sheltered life of these mice, but renders them hypersensitive to many drugs. P-glycoprotein appears to be especially important in protecting the brain and in limiting uptake of hydrophobic drugs from the gut. Recent experiments with polarized cells support the idea that drug-transporting P-glycoproteins act by flipping drugs from the inner to the outer leaflet of the plasma membrane. |
