| First Author | Icard-Liepkalns C | Year | 1997 |
| Journal | Eur J Biochem | Volume | 246 |
| Issue | 2 | Pages | 388-93 |
| PubMed ID | 9208929 | Mgi Jnum | J:41233 |
| Mgi Id | MGI:893312 | Doi | 10.1111/j.1432-1033.1997.00388.x |
| Citation | Icard-Liepkalns C, et al. (1997) An ADP-ribosylation-factor(ARF)-like protein involved in regulated secretion. Eur J Biochem 246(2):388-93 |
| abstractText | A rat ADP-ribosylation factor(ARF)-like protein named ARL184 was identified by cDNA cloning. The corresponding recombinant protein had an apparent molecular mass of 22,000. The deduced amino acid sequence had 55% identity with the human ARL1 and four functional GTP-binding sites. Immunofluorescent confocal microscopy studies showed that ARL184 was present in the cytosol as well as in the Golgi apparatus, raising the possibility that it has a role in a secretory pathway. The involvement of this ARF-like protein in secretion was confirmed by demonstrating that ARL184 potentiated acetylcholine release in stably transfected PC12 cells. Collectively these results suggest that this ARL protein is a component of a regulated secretory pathway involved in Ca2(+)-dependent release of acetylcholine. |
