| First Author | Hartley JW | Year | 1997 |
| Journal | Leukemia | Volume | 11 Suppl 3 |
| Pages | 147-8 | PubMed ID | 9209325 |
| Mgi Jnum | J:41196 | Mgi Id | MGI:893275 |
| Citation | Hartley JW, et al. (1997) Charlotte Friend Memorial Lecture: murine leukemia virus (MuLV) tumorigenesis. Leukemia 11 Suppl 3:147-8 |
| abstractText | Recent analysis of over 500 lymphomas occurring in NFS.V mice, congenic for Akv-type ecotropic MuLV structural genes, has revealed that about 90% are of B cell lineage as determined by demonstration of clonal rearrangements of Ig heavy chain genes, phenotyping by immunocytochemistry or cytofluorometric analysis, and by site and morphology of tumor. At least 40% of the B cell lymphomas were found to have their origin in the splenic marginal zone, a site only once before described for mouse lymphomas. Clonal somatic integrations of ecotropic MuLV occurred in 85% of tumors. |
