| First Author | Hattori K | Year | 1997 |
| Journal | Blood | Volume | 90 |
| Issue | 2 | Pages | 542-8 |
| PubMed ID | 9226153 | Mgi Jnum | J:41776 |
| Mgi Id | MGI:894472 | Doi | 10.1182/blood.v90.2.542.542_542_548 |
| Citation | Hattori K, et al. (1997) A metalloproteinase inhibitor prevents lethal acute graft-versus-host disease in mice. Blood 90(2):542-8 |
| abstractText | Tumor necrosis factor (TNF) and Fas ligand (FasL) have been implicated in the pathogenesis of graft-versus-host disease (GVHD), which is a major complication after allogeneic bone marrow transplantation. We examined here the ameliorating effect of a metalloproteinase inhibitor (KB-R7785) that inhibits TNF-alpha and FasL release in a lethal acute GVHD model in mice. Administration of KB-R7785 into (BALB/c x C57BL/6) F1 that received C57BL/6 spleen cells markedly reduced the mortality and weight loss in association with minimal signs of GVHD pathology in the liver, intestine, and hematopoietic tissues. The ameliorating effect of KB-R7785 was superior to that of anti-TNF-alpha antibody. Our results suggest that KB-R7785 could be a potent therapeutic agent for GVHD. |
