| First Author | Kobayashi T | Year | 1997 |
| Journal | Mamm Genome | Volume | 8 |
| Issue | 8 | Pages | 554-8 |
| PubMed ID | 9250859 | Mgi Jnum | J:42178 |
| Mgi Id | MGI:1095264 | Doi | 10.1007/s003359900502 |
| Citation | Kobayashi T, et al. (1997) Identification of a leader exon and a core promoter for the rat tuberous sclerosis 2 (Tsc2) gene and structural comparison with the human homolog. Mamm Genome 8(8):554-8 |
| abstractText | Hereditary renal carcinoma in the Eker rat is an excellent example of predisposition to a specific cancer being transmitted as a dominant trait. Recently, we identified a germline mutation of the tuberous sclerosis 2 (Tsc2) gene in the Eker rat. In the present study, we analyzed the upstream region of the Tsc2 gene. A novel leader exon (exon 1a) in a CpG island was found, and core promoter activity was identified in a 242-bp region of this island. Exon 1a and the promoter region were conserved in the human TSC2 gene. In addition, a rat homolog of a gene found upstream of TSC2 in human has been identified, indicating that the genomic organization around Tsc2/TSC2 is conserved between the two species. Characterization of the 5' region of Tsc2 and TSC2 will facilitate studies of the regulation of the gene and its disregulation in tumorigenesis. |
