| First Author | Lohmann SM | Year | 1997 |
| Journal | Trends Biochem Sci | Volume | 22 |
| Issue | 8 | Pages | 307-12 |
| PubMed ID | 9270304 | Mgi Jnum | J:42256 |
| Mgi Id | MGI:1095450 | Doi | 10.1016/s0968-0004(97)01086-4 |
| Citation | Lohmann SM, et al. (1997) Distinct and specific functions of cGMP-dependent protein kinases. Trends Biochem Sci 22(8):307-12 |
| abstractText | cGMP-dependent protein kinases I and II conduct signals from widespread signaling systems. Whereas the type I kinase mediates numerous effects of natriuretic peptides and nitric oxide in cardiovascular cells, the type II kinase transduces signals from the Escherichia coli heat-stable enterotoxin, STa, and from the endogenous intestinal peptide, guanylin, stimulating Cl- conductance of the cystic fibrosis transmembrane conductance regulator (CFTR). Although the two kinases may be interchangeable for several functions, CFTR regulation specifically requires the type II kinase. |
