| First Author | Peng Y | Year | 1997 |
| Journal | Genomics | Volume | 43 |
| Issue | 3 | Pages | 278-84 |
| PubMed ID | 9268630 | Mgi Jnum | J:42497 |
| Mgi Id | MGI:1095820 | Doi | 10.1006/geno.1997.4821 |
| Citation | Peng Y, et al. (1997) Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene. Genomics 43(3):278-84 |
| abstractText | Rat CL-6 is the most highly insulin-induced gene in a liver cell line and is expressed in proliferating liver during regeneration and development. CL-6 is now denoted INSIG1 (insulin-induced gene 1). Human INSIG1 was isolated and found to be 80% identical to the rat gene within the translated region. It was located on human chromosome 7 within band q36. The human INSIG1 promoter conferred a high level of expression in both liver and fibroblast cell lines. INSIG1 expression was upregulated at the transcriptional level in rat regenerating liver and induced in a model of murine adipocyte differentiation, suggesting that INSIG1 may play a role in growth and differentiation of tissues involved in metabolic control. |
