| First Author | Ortego J | Year | 1997 |
| Journal | FEBS Lett | Volume | 413 |
| Issue | 2 | Pages | 349-53 |
| PubMed ID | 9280311 | Mgi Jnum | J:47508 |
| Mgi Id | MGI:1203655 | Doi | 10.1016/s0014-5793(97)00934-4 |
| Citation | Ortego J, et al. (1997) Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin. FEBS Lett 413(2):349-53 |
| abstractText | A group of cDNAs isolated from a subtractive ciliary body library of a normal human eye donor revealed 100% identity with TIGR a candidate gene responsible for juvenile open zangle glaucoma [Science 275 (1997) 668-670]. Several structural features of the deduced human protein have been noted: a cleavable N-terminal signal peptide, a periodic repetition at the N-terminus of leucine and arginine residues at every seventh and eleven position respectively in helix conformation (leucine zipper-like motif) exhibiting homology with myosin, and with olfactomedin in the C-terminus. The mRNA for TIGR is abundantly expressed in the ciliary body, iris, heart and skeletal muscle. |
