| First Author | Lumniczky K | Year | 1997 |
| Journal | Radiat Oncol Investig | Volume | 5 |
| Issue | 3 | Pages | 158-62 |
| PubMed ID | 9303076 | Mgi Jnum | J:43883 |
| Mgi Id | MGI:1099092 | Doi | 10.1002/(SICI)1520-6823(1997)5:3<158::AID-ROI15>3.0.CO;2-2 |
| Citation | Lumniczky K, et al. (1997) Oncogenic changes in murine lymphoid tumors induced by in utero exposure to ionizing radiation. Radiat Oncol Investig 5(3):158-62 |
| abstractText | We have investigated the oncogenic alterations in murine lymphomas induced by in utero exposure to gamma-radiation. The expression of the myc oncogene increased in 23% of the tumors. Alterations in the expression of the ras oncogenes and in the p53 tumor suppressor gene were not characteristic. The p53 gene was mutated in a low percentage of the tumors (12%). Ras mutations were not detected. Loss of heterozygosity (LOH) at the p53 locus was found in 30% of the tumors, and LOH at the mts tumor suppressor gene was detected in 23% of lymphomas. Multiple oncogenic changes were infrequent in the investigated tumors. There were no essential differences in the frequency of carcinogenic alterations in spontaneous and gamma-radiation-induced lymphomas. |
