| First Author | Kitamura H | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 238 |
| Issue | 3 | Pages | 707-11 |
| PubMed ID | 9325153 | Mgi Jnum | J:43254 |
| Mgi Id | MGI:1097434 | Doi | 10.1006/bbrc.1997.7368 |
| Citation | Kitamura H, et al. (1997) Immobilization stress increases hepatic IL-6 expression in mice. Biochem Biophys Res Commun 238(3):707-11 |
| abstractText | When mice were subjected to restriction of movement in a small cylinder (immobilization stress), the serum interleukin (IL)-6 level rose in 1 h, following increased expression of IL-6 mRNA in both the liver and the spleen. The IL-6 mRNA induction was much greater in the liver than in the spleen when compared on a whole-organ basis. Intraperitoneal injection of bacterial lipopolysaccharide (LPS) also increased IL-6 mRNA expression in these organs, but more preferentially in the spleen. Immunohistochemical examinations of liver tissue using an antibody against murine IL-6 revealed that immobilization stress induced IL-6 mainly in hepatic parenchymal cells, whereas LPS injection did so only in sinusoidal mononuclear cells. These results indicate that immobilization stress induces IL-6 production in the liver, especially in hepatic parenchymal cells, probably by a different mechanism from that for IL-6 induction by LPS. |
