| First Author | Wu MC | Year | 1997 |
| Journal | Eur J Cancer | Volume | 33 |
| Issue | 10 | Pages | 1677-84 |
| PubMed ID | 9389933 | Mgi Jnum | J:43698 |
| Mgi Id | MGI:1098359 | Doi | 10.1016/s0959-8049(97)00162-7 |
| Citation | Wu MC, et al. (1997) Genome wide search for genetic damage in p53 transgenic mouse lung tumours reveals consistent loss of chromosome 4. Eur J Cancer 33(10):1677-84 |
| abstractText | The tumour which develops most frequently in mice carrying a p53 Val(135) transgene is adenocarcinoma of the lung. We established 10 cell Lines from these tumours and investigated their karyotypes by detailed cytogenetic analysis using a complete set of mouse chromosome-specific paints. Consistent loss of chromosome 4 material was noted in 9 out of 10 cell lines: this loss was detected in tetraploid but not diploid cells of the same cell line, suggesting that mouse chromosome 4 plays a critical role in the progression of lung adenocarcinomas. Other frequently observed chromosome aberrations involved chromosomes 7, 5 and 8. Atypical bronchial epithelium was observed together with lung tumours and in tumour-free, apparently normal lungs indicating that mouse lung tumours induced due to the presence of a mutant p53 transgene may develop via pre-invasive lesions and thus may be effective models for the study of lung tumour progression. (C) 1997 Elsevier Science Ltd. |
