| First Author | Cox LS | Year | 1997 |
| Journal | J Pathol | Volume | 183 |
| Issue | 2 | Pages | 134-40 |
| PubMed ID | 9390024 | Mgi Jnum | J:43463 |
| Mgi Id | MGI:1097764 | Doi | 10.1002/(SICI)1096-9896(199710)183:2<134::AID-PATH960>3.0.CO;2-D |
| Citation | Cox LS (1997) Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1. J Pathol 183(2):134-40 |
| abstractText | Many tumour therapies act by inducing a cellular damage response pathway mediated by the tumour suppressor protein p53. Alternative outcomes of p53 induction include apoptosis or transient cell-cycle arrest, both thought to require the transcriptional activity of wild-type p53. Current research highlights the action of a p53-activated gene, p21Cip1/WAF1/Sdi1, which encodes a cyclin-kinase inhibitor important in mediating p53-dependent cell-cycle arrest, while programmed cell death in response to DNA damage requires transcriptionally active p53 but not activation of p21Cip1/WAF1/Sdi1. This review examines the roles of p53 and p21Cip1/WAF1/Sdi1 in controlling cell proliferation, in the light of a new study on expression of p53 and p21Cip1/WAF1/Sdi1 in squamous cell carcinoma of the larynx. |
