| First Author | Inagaki-Ohara K | Year | 1997 |
| Journal | Eur J Immunol | Volume | 27 |
| Issue | 11 | Pages | 2885-91 |
| PubMed ID | 9394814 | Mgi Jnum | J:44505 |
| Mgi Id | MGI:1100389 | Doi | 10.1002/eji.1830271121 |
| Citation | Inagaki-Ohara K, et al. (1997) Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing gamma delta T cell receptor in mice. Eur J Immunol 27(11):2885-91 |
| abstractText | Several cytokines including stem cell factor (SCF) and interleukin (IL)-7 are known to be required for development of gamma delta T cell receptor (TCR) intestinal intraepithelial lymphocytes (i-IEL) in mice. We show here the effects of IL-15 on the proliferation and maintenance of murine gamma delta i-IEL in vitro. gamma delta i-IEL constitutively expressed a high level of IL-15 receptor alpha mRNA and proliferated in response to IL-15 more vigorously than alpha beta i-IEL. V gamma/delta repertoire analysis revealed that IL-15, like IL-2, induced polyclonal expansion of gamma delta i-IEL, whereas gamma delta i-IEL responding to IL-7 showed a V gamma/delta repertoire skewed towards V gamma 1/V delta 4, V delta 5. IL-15 efficiently prevented gamma delta i-IEL from apoptosis induced by growth factor deprivation. This rescue was accompanied by up-regulation of Bcl-2 expression. These results suggest that IL-15 plays important roles in proliferation and maintenance of gamma delta i-IEL. |
