| First Author | Desseyn JL | Year | 1998 |
| Journal | J Mol Evol | Volume | 46 |
| Issue | 1 | Pages | 102-6 |
| PubMed ID | 9419229 | Mgi Jnum | J:44814 |
| Mgi Id | MGI:1101360 | Doi | 10.1007/pl00006276 |
| Citation | Desseyn JL, et al. (1998) Evolutionary history of the 11p15 human mucin gene family. J Mol Evol 46(1):102-6 |
| abstractText | The four human mucin genes MUC6, MUC2, MUC5AC, and MUC5B are located at chromosome 11p15.5. It has been demonstrated that the three mucins MUC2, MUC5AC, and MUC5B contain several Cys-subdomains of 108 amino acid residues. In contrast, little information is available concerning MUC6. These Cys-subdomains contain 10 cysteine residues that have a highly conserved position. We present here a coherent probable evolutionary history of this human gene family after comparison of the nucleotide sequences of these Cys-subdomains. The three MUC loci MUC2, MUC5AC, and MUC5B may have evolved from a common ancestral gene by two successive duplications. Moreover, we can postulate that MUC5AC and MUC5B have evolved in a concerted manner, while MUC2 has evolved separately. |
