| First Author | Vougioukas VI | Year | 1998 |
| Journal | Am J Pathol | Volume | 152 |
| Issue | 1 | Pages | 241-9 |
| PubMed ID | 9422541 | Mgi Jnum | J:45589 |
| Mgi Id | MGI:1195744 | Citation | Vougioukas VI, et al. (1998) Wallerian degeneration in ICAM-1-deficient mice. Am J Pathol 152(1):241-9 |
| abstractText | Wallerian degeneration of the peripheral nervous system was studied in ICAM-1-deficient mice and compared with the phenomena observed in C57BL wild-type animals. There was a decrease in myelin density in both mice strains 4 and 6 days after transection of the sciatic nerve. The degenerating nerves were invaded by Mac-1-, LFA-1-, and F4/80-positive macrophages; significantly lower numbers of macrophages were present in ICAM-1-deficient nerves. Myelin loss decreased after nerve transection with a more prominent loss in ICAM-1-deficient animals. Schwann cells revealed a much higher myelin load in these animals when compared with wild-type nerves, and there was an increased proliferation of endoneurial cells in ICAM-1-deficient mice. These data indicate that ICAM-1 is involved in macrophage recruitment to injured peripheral nerves as well as in the proliferative and phagocytic response of Schwann cells after peripheral nerve transection. |
