| First Author | Fehling HJ | Year | 1997 |
| Journal | Curr Opin Immunol | Volume | 9 |
| Issue | 2 | Pages | 263-75 |
| PubMed ID | 9099797 | Mgi Jnum | J:39763 |
| Mgi Id | MGI:87112 | Doi | 10.1016/s0952-7915(97)80146-x |
| Citation | Fehling HJ, et al. (1997) Early alpha beta T cell development in the thymus of normal and genetically altered mice. Curr Opin Immunol 9(2):263-75 |
| abstractText | The vast majority of T lymphocytes, with the exception of gut-associated, intraepithelial lymphocytes, differentiate and mature inside the thymus. Early T cell development is characterized by expansion and differentiation of thymocytes which do not yet express mature TCRs on their cell surface. Important events in early thymocyte development are controlled by a pre-TCR complex consisting of a conventional TCR beta chain and a novel transmembrane protein termed pre-TCR alpha (p T alpha chain) which are noncovalently associated with components of CD3. Recent studies of pre-TCR function have led to a better understanding of the molecular events in early thymocyte development. |
