| First Author | Lu P | Year | 1997 |
| Journal | Curr Opin Immunol | Volume | 9 |
| Issue | 6 | Pages | 858-62 |
| PubMed ID | 9492990 | Mgi Jnum | J:45815 |
| Mgi Id | MGI:1196145 | Doi | 10.1016/s0952-7915(97)80190-2 |
| Citation | Lu P, et al. (1997) Regulation of self-tolerance by CD80/CD86 interactions. Curr Opin Immunol 9(6):858-62 |
| abstractText | Antigen presentation by CD80/CD86-positive 'professional APCs' induces T-cell activation, whereas antigen presentation in the absence of sufficient CD80/CD86 costimulation may induce a form of tolerance. Blocking CD80/CD86 constimulation inhibits autoimmune disease progression in a variety of animal models, but whether these effects result from restoration of self-tolerance or temporary disease blockade is still unclear. The individual roles of CD80 and CD86 in autoimmune diseases are complicated by multiple-factors in vivo. Data from B7 gene knockout mice further clarify the importance of CD80/CD86 in the regulation of T-cell activation and tolerance. |
