| First Author | Suzumura A | Year | 1998 |
| Journal | Brain Res | Volume | 787 |
| Issue | 1 | Pages | 139-42 |
| PubMed ID | 9518583 | Mgi Jnum | J:47150 |
| Mgi Id | MGI:1202668 | Doi | 10.1016/s0006-8993(97)01166-9 |
| Citation | Suzumura A, et al. (1998) Production of interleukin-12 and expression of its receptors by murine microglia. Brain Res 787(1):139-42 |
| abstractText | Production of interleukin-12 (IL-12) by cultured murine microglia and astrocytes was examined, by means of ELISA to detect heterodimeric p70 and RT-PCR to analyze the expression of mRNA encoding p35 and p40. Microglia, but not astrocytes, produced IL-12 p70 in response to lipopolysaccharide and interferon-gamma. The microglial cell line, Ra2, produced only p40, but not p35, upon above stimulation. Thus, it is possible that some population of microglia induce helper 1 type T cell response via producing IL-12 in the CNS. Microglia were induced to express mRNA encoding IL-12 receptors which were exclusively expressed in activated T and NK cells. Copyright 1998 Elsevier Science B.V. |
