| First Author | Kagami O | Year | 1998 |
| Journal | Gene | Volume | 211 |
| Issue | 2 | Pages | 383-6 |
| PubMed ID | 9602174 | Mgi Jnum | J:47730 |
| Mgi Id | MGI:1205970 | Doi | 10.1016/s0378-1119(98)00128-0 |
| Citation | Kagami O, et al. (1998) A dynein light chain of sea urchin sperm flagella is a homolog of mouse Tctex 1, which is encoded by a gene of the t complex sterility locus. Gene 211(2):383-6 |
| abstractText | The outer-arm dynein of sea urchin sperm flagella contains six light chains with molecular masses of 23.2, 20.8, 12.3, 11.5, 10.4 and 9.3 kDa. We have cloned a cDNA for the 12.3 kDa polypeptide (light chain 3) and found that this protein is highly homologous to mouse Tctex1, a protein encoded by a member of the multigene family in the t complex region that is involved in male sterility and the development of the germ cells. Tctex1 has recently been shown to be homologous to a light chain of cytoplasmic dynein. Therefore, the cytoplasmic dynein light chain has been implicated in the mechanism for the transmission ratio distortion (meiotic drive) that is characteristic of t haplotypes in mice. Our present finding, however, indicates that axonemal light chain 3 must be considered equally important. (C) 1998 Elsevier Science B.V. All rights reserved. |
