| First Author | McKee-Johnson JW | Year | 1998 |
| Journal | Genomics | Volume | 49 |
| Issue | 3 | Pages | 371-7 |
| PubMed ID | 9615221 | Mgi Jnum | J:47939 |
| Mgi Id | MGI:1206512 | Doi | 10.1006/geno.1998.5274 |
| Citation | McKee-Johnson JW, et al. (1998) Physical and genetic maps of the deafwaddler region on distal mouse Chr 6. Genomics 49(3):371-7 |
| abstractText | The deafwaddler (dfw) mutation, displaying motor ataxia and profound deafness, arose spontaneously in a C3H/HeJ colony and was mapped previously to distal mouse Chr 6. In this study, a high-resolution genetic map was generated by positioning 10 microsatellite markers and 5 known genes on a 968-meioses intersubspecific backcross segregating for dfw, [(CAST/Ei-+/+ x C3HeB/ FeJ-dfw/dfw) x C3HeB/FeJ-dfw/ dfw], giving the following marker order and sex-averaged distances: D6Mit64-(0.10 + 0.10 cM)-Pang-(1.24 + 0.36 cM)- Itpr1-(0.62 + 0.25 cM)-D6Mit108-(0.52 + 0.23 cM)-D6Mit54- (0.21 + 0.15 cM)-D6Mit23, D6Mit107, D6Mit328-(0.72 + 0.27 cM)-D6Mit11-(0.21 + 0.15 cM)-dfw-(0.93 + 0.31 cM)-Gat4, D6Mit55-(0.10 + 0.10 cM)-D6Mit63-(0.31 + 0.18 cM)-Syn2- (0.62 + 0.25 cM)-D6Mit44 (Rho). Female and male genetic maps are similar immediately surrounding the dfw locus, but show marked differences in other areas. A yeast artificial chromosome-based physical map suggests that the closest markers flanking the dfw, locus, D6Mit11 (proximal) and Gat4, D6Mit55 (distal), are contained within 650-950 kb, The human homologues of the flanking loci Itpr1 (proximal) and Syn2 (distal) map to chromosome 3p25-p26, suggesting that the human homologue of the dfw, gene is located within this same region. (C) 1998 Academic Press. |
