| First Author | Becker KP | Year | 1998 |
| Journal | Biochim Biophys Acta | Volume | 1403 |
| Issue | 1 | Pages | 109-14 |
| PubMed ID | 9622606 | Mgi Jnum | J:48187 |
| Mgi Id | MGI:1266922 | Doi | 10.1016/s0167-4889(98)00019-6 |
| Citation | Becker KP, et al. (1998) Cloning and characterization of an endogenous COS-7 cell thromboxane A2 receptor. Biochim Biophys Acta 1403(1):109-14 |
| abstractText | A cDNA for a thromboxane A2 (TXA2) receptor was cloned from an SV40 transformed African Green Monkey kidney cell line (COS-7). The sequence is 98% homologous with the isoform of the human TXA2 receptor and has agonist and antagonist ligand binding characteristics that are not significantly different from the human receptor. Stimulation of the COS-7 cells with the TXA2 receptor agonist, ONO 11113 resulted in a significant increase in cAMP formation that was blocked by a receptor antagonist. The results raise the question of the utility of the COS-7 cell line for studies of cloned and expressed TXA2 receptor signalling mechanisms. Copyright 1998 Elsevier Science B.V. All rights reserved. |
