| First Author | Feldman JD | Year | 1998 |
| Journal | J Biol Chem | Volume | 273 |
| Issue | 26 | Pages | 16535-43 |
| PubMed ID | 9632723 | Mgi Jnum | J:48321 |
| Mgi Id | MGI:1267171 | Doi | 10.1074/jbc.273.26.16535 |
| Citation | Feldman JD, et al. (1998) KID-1, a protein kinase induced by depolarization in brain. J Biol Chem 273(26):16535-43 |
| abstractText | Membrane depolarization leads to changes in gene expression that modulate neuronal plasticity. Using representational difference analysis, we have identified a previously undiscovered cDNA, KID-1 (kinase induced by depolarization), that is induced by membrane depolarization or forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells. KID-1 is an immediate early gene that shares a high degree of sequence similarity with the family of PIM-1 serine/threonine protein kinases. Recombinant KID-1 fusion protein is able to catalyze both histone phosphorylation and autophosphorylation. KID-1 mRNA is present in a number of unstimulated tissues, including brain. In response to kainic acid and electroconvulsive shock-induced seizures, KID-1 is induced in specific regions of the hippocampus and cortex. |
