| First Author | Muramatsu T | Year | 1998 |
| Journal | Biochem Biophys Res Commun | Volume | 247 |
| Issue | 1 | Pages | 7-11 |
| PubMed ID | 9636644 | Mgi Jnum | J:48043 |
| Mgi Id | MGI:1261669 | Doi | 10.1006/bbrc.1998.8657 |
| Citation | Muramatsu T, et al. (1998) BC1 RNA protein particles in mouse brain contain two y-,h-element-binding proteins, translin and a 37 kDa protein. Biochem Biophys Res Commun 247(1):7-11 |
| abstractText | Neural BC1 RNA is distributed in dendrites in the form of ribonucleoprotein particles (RNP). Recently, Han et al. reported that testis-brain RNA-binding protein (the mouse homologue of Translin), known to be a translational repressor, links a subset of mRNAs to microtubules (MTs) through binding to their y-,h-sequence elements. We found that similar elements are also present in BC1 RNA. Therefore, it is possible that they also act as cis-elements, together with their transacting proteins, and control the transport of BC1 RNA along dendritic MTs. In this study, we demonstrated that two y-,h-element-binding proteins copurified with BC1 RNP. One was identified as mouse Translin and the other was a 37 kDa protein. This macromolecular assembly may constitute a transport particle for BC1 RNA. It is also possible that BC1 RNP or Translin itself may play a regulatory role(s) in the translation of mRNAs within dendrites. |
