| First Author | Liu KD | Year | 1998 |
| Journal | Curr Opin Immunol | Volume | 10 |
| Issue | 3 | Pages | 271-8 |
| PubMed ID | 9638363 | Mgi Jnum | J:48063 |
| Mgi Id | MGI:1261689 | Doi | 10.1016/s0952-7915(98)80165-9 |
| Citation | Liu KD, et al. (1998) JAK/STAT signaling by cytokine receptors. Curr Opin Immunol 10(3):271-8 |
| abstractText | The JAK/STAT pathway is recognized as one of the major mechanisms by which cytokine receptors transduce intracellular signals. This system is regulated at multiple levels, including JAK activation, nuclear trafficking of STAT factors, and negative feedback loops. Gene deletion studies have implicated selected STAT factors as predominant mediators for a limited number of lymphokines. This signaling pathway influences normal cell survival and growth mechanisms and may contribute to oncogenic transformation. |
