| First Author | Kim HS | Year | 1998 |
| Journal | J Leukoc Biol | Volume | 64 |
| Issue | 1 | Pages | 33-9 |
| PubMed ID | 9665272 | Mgi Jnum | J:48483 |
| Mgi Id | MGI:1270050 | Doi | 10.1002/jlb.64.1.33 |
| Citation | Kim HS, et al. (1998) IL-10 suppresses LPS-induced KC mRNA expression via a translation-dependent decrease in mRNA stability. J Leukoc Biol 64(1):33-9 |
| abstractText | This study examines the mechanism of interleukin-10 (IL-10)-mediated suppression of KC chemokine gene expression in mouse macrophages. Suppression of KC mRNA levels by IL-10 occurred late in the time course of response to lipopolysaccharide (LPS). Equivalent IL-10-mediated suppression was observed when the agent was added 1 h before, simultaneous with, or 1 h after LPS. IL-10 did not inhibit KC gene transcription but rather produced a decrease in the stability of KC mRNA. The suppressive action of IL-10 was prevented in macrophages that were also treated with inhibitors of protein synthesis even when added 2 h after LPS and IL-10. These results suggest that IL-10 acts to destabilize LPS-induced KC mRNA through a process that depends on coincident KC mRNA translation. |
