| First Author | Le Calvez S | Year | 1998 |
| Journal | Hear Res | Volume | 120 |
| Issue | 1-2 | Pages | 51-61 |
| PubMed ID | 9667430 | Mgi Jnum | J:48383 |
| Mgi Id | MGI:1267276 | Doi | 10.1016/s0378-5955(98)00051-3 |
| Citation | Le Calvez S, et al. (1998) CD1 hearing-impaired mice. II. Group latencies and optimal f2/f1 ratios of distortion product otoacoustic emissions, and scanning electron microscopy. Hear Res 120(1-2):51-61 |
| abstractText | In our companion paper (Le Calvez et al., 1998), the levels of distortion product otoacoustic emissions (DPOAE) were collected in the ears of CD1 mice with progressive degeneration of cochlear outer hair cells (OHC). Their comparison to standard functional measurements such as auditory-evoked brainstem responses (ABR) showed that CD1 ears could be classified as normal or impaired in a frequency-specific manner using DPOAE levels. The present work reports how DPOAE phases and levels of young CD1 mice were affected by varying the frequency ratio of eliciting stimuli at frequencies f(1) and f(2). Normally hearing CBA/ J mice served as controls. The rate of phase change of DPOAE when f(1) was varied and f(2) was fixed allowed the group delay of DPOAE to be derived. The changes of DPOAE levels during this procedure disclosed bandpass characteristics that several reports (Fahey and Alien, 1986; Brown and Gaskill, 1990) assumed to be the reflection of important features uf cochlear micromechanics, possibly in relation to the coupling of OHCs to the tectorial membrane. Group delays became significantly shorter when ABR thresholds exceeded 40 dB elevation. The bandpass filter characteristics strikingly depended on auditory function so that the optimal ratio f(2)/f(1) progressively shifted from 1.24 to 1.50 or more when hearing loss increased. A difference was also noted between CD1 ears whose ABR thresholds were not yet increased and control CBA/J (optimal ratio 1.20). Scanning electron microscopy disclosed a variety of often minor OHC lesions that were only roughly correlated with cochlear function. However, the presence of abnormalities in the reticular lamina associated with early changes of DPOAE fine structure as a function of f(2)/f(1) supported the hypothesis of some involvement of micromechanical features in the bandpass filter characteristics of DPOAE, The sensitivity of their measurement in pathological situations is potentially interesting. (C) 1998 Elsevier Science B.V. All rights reserved. |
