| First Author | Zhao ML | Year | 1998 |
| Journal | J Neuroimmunol | Volume | 87 |
| Issue | 1-2 | Pages | 171-8 |
| PubMed ID | 9670859 | Mgi Jnum | J:49388 |
| Mgi Id | MGI:1277429 | Doi | 10.1016/s0165-5728(98)00083-6 |
| Citation | Zhao ML, et al. (1998) Acute and relapsing experimental autoimmune encephalomyelitis in IL-4-and alpha/beta T cell-deficient C57BL/6 mice. J Neuroimmunol 87(1-2):171-8 |
| abstractText | Experimental autoimmune encephalomyelitis follows a chronic relapsing course in several inbred strains of mice. To address the role of T cells in recovery and relapse, the clinical course of EAE was compared in C57BL/6 (B6) normal and immunodeficient mice following active immunization with MOG p35-55 or adoptive transfer of encephalitogenic peptide-specific T cell lines. The course of actively-induced EAE in B6 wild-type and IL-4 -/- mice was similar. B6 IL-4 -/- mice recovered normally from acute passive EAE, but did not relapse in contrast to wild-type B6 mice. EAE was progressive in B6 RAG -/- and alpha/beta TCR -/- mice, but the disease course could be arrested by infusion of normal spleen cells. When non-activated MOG peptide-specific T cells were transferred to wild-type or alpha/beta TCR -/- mice, spontaneous disease ensued in the mutants only. |
