| First Author | Jing X | Year | 1998 |
| Journal | Neurosci Res | Volume | 30 |
| Issue | 4 | Pages | 343-9 |
| PubMed ID | 9678638 | Mgi Jnum | J:49030 |
| Mgi Id | MGI:1276333 | Doi | 10.1016/s0168-0102(98)00017-0 |
| Citation | Jing X, et al. (1998) Ontogeny of the vasopressin and oxytocin RNAs in the mouse hypothalamus. Neurosci Res 30(4):343-9 |
| abstractText | The single-copy genes encoding the vasopressin and oxytocin prepropeptides are closely linked in mouse genome, being separated by an intergenic region of only 3 kbp. These genes are expressed in anatomically defined hypothalamic neurons--in the adult rodent, vasopressin is synthesised in the paraventricular nucleus and the supraoptic nucleus, and in the dorsomedial region of the suprachiasmatic nucleus, whilst oxytocin is expressed in the supraoptic nucleus and paraventricular nucleus, but not in the suprachiasmatic nucleus. The molecular mechanisms that mediate the cell-specific and developmental expression patterns of the two transcription units within the vasopressin-oxytocin locus remain to be elucidated. As a first step in this process, we have used in situ hybridisation to study the expression of the RNAs encoded by the linked vasopressin and oxytocin genes during the development of the mouse hypothalamus. We have revealed a hierarchy of gene activation events, with vasopressin first being observed in presumptive supraoptic nucleus at day 13.5, and in the paraventricular at day 14.5. Oxytocin is seen first in the paraventricular at day 15.5; expression in the supraoptic nucleus is clearly seen at day 18.5. As early as day 15.5, the vasopressin and oxytocin RNAs are expressed in different groups of neurons. |
