| First Author | Terres G | Year | 1998 |
| Journal | Int Immunol | Volume | 10 |
| Issue | 6 | Pages | 823-32 |
| PubMed ID | 9678764 | Mgi Jnum | J:48264 |
| Mgi Id | MGI:1267114 | Doi | 10.1093/intimm/10.6.823 |
| Citation | Terres G, et al. (1998) The role of IL-4 and IL-10 cytokines in controlling an anti-tumor response in vivo. Int Immunol 10(6):823-32 |
| abstractText | The effect of systemic administration of anti-inflammatory cytokines (IL-4 and IL-10) on the development and maintenance of an anti-tumor rejection response in vivo was studied by following the growth patterns of P815.B7 tumors on B6D2F1 [(C57BI/6 x DBA/2)F1] mice. The anti-P815.B7 rejection response was found to be T cell dependent, involving both CD4 and CD8 cells. IL-4 treatment resulted in a compromised rejection response; IL-10 treatment alone had little or no effect. These results demonstrate that treatment with an anti-inflammatory cytokine can compromise an otherwise effective anti-tumor rejection response. For the anti-inflammatory cytokine IL-4, the immunosuppressive effects of the cytokine appear to outweigh any possible anti-tumor activities as have been reported using tumor cells genetically altered to produce IL-4. Relatively high systemic doses of IL-10, in contrast, were not immunosuppressive and, when given in combination with IL-4, countered the IL-4 suppressive effect. Pathologically, IL-4 treatment led to splenomegaly characterized by a marked increase in neutrophils and NK activity. The possible linkages between neutrophils, NK activity and IL-12 are discussed. |
