| First Author | Opdecamp K | Year | 1998 |
| Journal | Mamm Genome | Volume | 9 |
| Issue | 8 | Pages | 617-21 |
| PubMed ID | 9680380 | Mgi Jnum | J:48974 |
| Mgi Id | MGI:1276277 | Doi | 10.1007/s003359900832 |
| Citation | Opdecamp K, et al. (1998) The rat microphthalmia-associated transcription factor gene (Mitf) maps at 4q34-q41 and is mutated in the mib rats. Mamm Genome 9(8):617-21 |
| abstractText | The rat gene encoding the microphthalmia-associated transcription factor (Mitf) was assigned to rat Chromosome (Chr) 4q34-q41, as well as the Gata2 and Mem1 genes. Rat Chr 4 is homologous to mouse Chr 6 and human Chr 3, which carry the Mitf (MITF) gene in these species (MMU 6, 40.0 cM, and HSA 3p14.1-p12.3). mib/mib rats, which are characterized by depigmentation, microphtalmy, osteopetrosis, and neurological disorders were shown to bear a deletion covering several kilobases of genomic DNA in the Mitf gene and to lack Mitf mRNA. The Mitf mutation in the mib/mib rats is thus very likely to be a Mitf null mutation, causing a phenotype similar to the one observed in the miVGA-9 mice, but including osteopetrosis as an additional feature. |
