| First Author | Norton JD | Year | 1998 |
| Journal | Trends Cell Biol | Volume | 8 |
| Issue | 2 | Pages | 58-65 |
| PubMed ID | 9695810 | Mgi Jnum | J:45813 |
| Mgi Id | MGI:1196143 | Citation | Norton JD, et al. (1998) Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol 8(2):58-65 |
| abstractText | Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of higher eukaryotes. In addition, the functions of Id proteins are integrated with cell-cycle-regulatory pathways orchestrated by cyclin-dependent kinases and the retinoblastoma protein. Here, some of the recent advances that highlight the importance of Id proteins as regulatory intermediates for coordinating differentiation-linked gene expression with cell-cycle control in response to extracellular signalling are reviewed. |
