| First Author | Kelekar A | Year | 1998 |
| Journal | Trends Cell Biol | Volume | 8 |
| Issue | 8 | Pages | 324-30 |
| PubMed ID | 9704409 | Mgi Jnum | J:48869 |
| Mgi Id | MGI:1275902 | Doi | 10.1016/s0962-8924(98)01321-x |
| Citation | Kelekar A, et al. (1998) Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol 8(8):324-30 |
| abstractText | Bcl-2-related proteins have come to occupy a prominent position in the realm of programmed cell death. Members of this fast-growing family are highly related in one or more specific regions, commonly referred to as Bcl-2 homology (BH) domains. BH domains contribute at multiple levels to the function of these proteins in cell death and survival. Particularly intriguing is the emergence of the BH3 domain as a potent 'death domain' and of a growing subclass of pro-apoptotic proteins with no similarity to Bcl-2 beyond their BH3 homology. Here, the authors classify proteins of the Bcl-2 family on the basis of function and domain organization, discuss the importance of the BH3 domain in protein-protein interactions and in cell death and provide possible explanations for the perceived redundancy in the expression of this subclass of death promoters. |
