| First Author | Kumar N | Year | 1998 |
| Journal | Immunology | Volume | 94 |
| Issue | 1 | Pages | 28-34 |
| PubMed ID | 9708183 | Mgi Jnum | J:47758 |
| Mgi Id | MGI:1205998 | Doi | 10.1046/j.1365-2567.1998.00486.x |
| Citation | Kumar N, et al. (1998) Evidence for epitope-specific thymus-independent response against a repeat sequence in a protein antigen. Immunology 94(1):28-34 |
| abstractText | We have studied the immunogenicity of a recombinant heat-shock protein-related stress protein of 70,000 MW (Pfhsp) of the human malaria parasite Plasmodium falciparum in H-2 congenic and non-congenic strains of inbred and outbred mice. Most mice of different genetic backgrounds produced antibodies to Pfhsp, indicating a lack of any apparent genetic restriction of immune response. A peptide corresponding to the GGMP repeat sequence in the C-terminal region of Pfhsp was recognized by more than 75% of sera from immunized mice. The GGMP repeat epitope-specific antibodies were largely of the IgM isotype, especially in all seven inbred strains of mice tested. The lack of significant boosting of the immune response, a predominantly IgM isotype of antibodies and generation of antibody responses in athymic nude mice suggest a thymus-independent response against the GGMP repeat epitope in the Pfhsp molecule. |
